I'm pulling out the BOLD Comic-Sans for this one, kids.
Let us "pretend" for a moment that you are a business (or other entity) with a message to send or a product to pitch. You have a large customer base or list and many people on your email list and perhaps lots of methods of reaching these potential customers.
1. Please spell-check your copy before you publish it.
READ YOUR SHIT.
Let someone outside of your house read your "PROFESSIONAL" website.
2. Please consider that we are in 2013 and many people have moved beyond Comic Sans.